You’d probably want to segregate the hard-tech from the soft/bio-tech:
IF you require deterministic-performance, THEN stay away from meat-implimentation.
IF you require sentience-sensitivity, THEN stay away from hard-tech implimentation.
( same principle as requiring both people & systems, in order to project effective force, economically, militarily, in disaster-relief, in any domain,
same principle as using both a wordsless-wholistic metaphor-understanding sentience in one’s right-hemisphere, vs a reductionistic sentience in one’s left, as the split-brain patients showed.
2 orthogonal systems, collaborating … produces greater results than either-kind would on its own! )
Organic-sentience and machine-compute, organic doing the high-level-decisions, & machines doing the low-level-competencies, seems much more realistic.
Many years ago, it was discovered that Wine could run Windows viruses/worms/malware just fine, thank you very much…
“Sandboxing”, it isn’t.
It runs with all the privileges of the user running the app, iirc.