Ccx [they/them/🐰]

Thanks!

Interestingly I can’t find any such mention in the database of drugs sold locally. Closest I’ve seen was interaction warning for methylphenidate with alpha2 agonist medication. Which caffeine isn’t but such agonist would have indirect effect on adenosine which is the same thing caffeine primarily affects. But the warning wasn’t about effectiveness but about safety.

I’ll have to look up actual studies on it later. If I remember. :-)

What was the constant warning across stimulant medications that I’ve seen is about anything which affects blood pressure and heart rate, as safety concern. And caffeine would fall under that given sufficient dosage.

Even if it doesn’t bring anything novel having confirmed results is good in science.

Open access PDF of the study can be obtained here: https://www.cell.com/cell/fulltext/S0092-8674(25)01373-X

Norepinephrine is another neurotransmitter highly implicated in ADHD.

Quoting from Wikipedia: Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention; it also increases restlessness and anxiety.

The trouble of being to regulate wakefulness has been in my personal experience more pronounced than attention jumping around. But that’s likely fairly individual. I wouldn’t be surprised if the inattentive subtype & hyperactive subtype categories we use now were related to balance of these two.

Thankfully I’m more of album listener than song listener so this happens way less, but still the best I’ve found so far were:

• curated playlists, especially those promoting indie artists’ new releases (I wish had better source for those than YT)
• friend group swapping recommendations

I don’t think that applies to ADHD related medication in general. Pehaps to stimulant-based ones? Do you have any references on it?